VITAMIN D3+K2 DROPS 30 ML

Description
Dietary supplement containing plant-based vitamins D3 and K2 in sunflower seed oil. With lemon and orange essential oils. The product is indicated for promoting bone mineralization by promoting the absorption/utilization of calcium and phosphorus. It is therefore effective in improving postmenopausal osteoporosis by improving bone density and reducing the risk of fractures. It also has beneficial effects on muscle contraction and trophism as well as stimulating the immune system.

Ingredients
Sunflower seed oil, vitamin D (cholecalciferol) extracted from lichen [Cladonia rangiferina (L.) Weber ex F.H. Wigg.], vitamin K2 (menaquinone-7); antioxidant: alpha-tocopherol; orange (Citrus aurantium var. dulcis Hayne) essential oil, lemon [Citrus limon (L.) Osbeck.] essential oil.

Nutritional characteristics

Average values	For 12 drops equal to 0.5 ml
Vitamin D3 from lichen	50 mcg (1.000% NRV*)
Vitamin K2 (menaquinone-7)	25 mcg (33% NRV*)
Lemon oe	0.2 mg
Orange oe	0.2 mg

*NRV: Nutrient Reference Values.

How to use
-Adults: We recommend taking a maximum of 12 drops per day.
-Adolescents and pregnant women: it is recommended to take a maximum of 6 drops per day.
-Children aged 3 years and over: it is recommended to take a maximum of 3 drops per day.

Warnings
Do not exceed the recommended daily dose. Keep out of reach of children under 3 years of age. Food supplements should not be used as a substitute for a varied and balanced diet and lifestyle. Interactions or side effects: Vitamin K is known to interact with anticoagulant drugs.

Conservation
Store tightly closed in a cool, dry place, away from light. The expiration date refers to the product stored properly in its intact packaging.

Format
Capacity: 30 ml.

Bibliography
1. AA.VV. - PDR Nutritional Supplements, CEC Editore, Milan, 2003.
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3. Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. (2010) Vitamin D: modulator of the immune system. Curr Opin Pharmacol.
4. Aranow, Cynthia. (2011) “Vitamin D and the immune system.” Journal of investigative medicine: the official publication of the American Federation for Clinical Research vol. 59.6: 881-6. doi: 10.2310/JIM.0b013e31821b8755
5. Simes DC, Viegas CSB, Araújo N, Marreiros C. (2019) Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies. Int J Mol Sci.A. Spiro and JL Buttriss, (2014) "Vitamin D: an overview of vitamin D status and intake in Europe," Nutrition Bulletin, vol. 39, pp. 322-350.
6. JC Fleet, (2017) "The role of vitamin D in the endocrinology controlling calcium homeostasis," Molecular and Cellular Endocrinology, vol. 17, pp. 30221-30226.
7. Adriana J. van Ballegooijen et al (2007) The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review International Journal of Endocrinology.
8. Beulens J et al (2013) The role of menaquinones (vitamin K2) in human health. Br J Nutr 110(8):1357–1368.
9. Maresz K (2015) Proper calcium use: Vitamin K2 as a promoter of bone and cardiovascular health. Integr Health 14(1):34-39.
10.Ikeda Y et al (2006) Intake of Fermented Soybeans, Natto, Is Associated with Reduced Bone Loss in Postmenopausal Women: Japanese Population-Based Osteoporosis (JPOS) Study.J Nutr 136(5):1323-1328.
11. Inaba N et al (2015) Low-Dose Daily Intake of Vitamin K2 (Menaquinone-7) Improves Osteocalcin?- Carboxylation: A Double-Blind, Randomized Controlled Trial. J Nutr Sci Vitaminol (Tokyo) 61(6):471-480.
12. Knapen M et al (2013) Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporosis Int 24(9):2499–2507.
13.Geleijnse J et al (2004) Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam study.